CAN DEMENTIA BE CURED: NEW DRUG WITH NEW WARNINGS

CNN recently featured its medical expert, neurologist Sanjay Gupta, narrating a very thorough documentary entitled "The Last Alzheimer's Patient" which, over a 5 year period, collected data on the latest research related to dementia, highlighting advances in new medications as well as in lifestyle changes, both of which offer promising developments that may, in some cases, reverse or, at least stop the advance of Alzheimer's, the most common form of dementia. What is Alzheimer's Disease (AD)? According to the Yale School of Medicine, AD "is a progressive disorder that damages and destroys nerve cells in the brain. Over time, the disease leads to a gradual loss of cognitive functions, including the ability to remember, reason, use language, and recognize familiar places. It can also cause a range of behavioral changes."

The Food and Drug Administration (FDA) recently granted full approval to a new Alzheimer’s treatment called lecanemab, which has been shown to moderately slow cognitive and functional decline in early-stage cases of the disease. “It’s very exciting because this is the first treatment in our history that shows an unequivocal slowing of decline in Alzheimer’s disease,” says Dr. Christopher van Dyck of Yale who was the lead author on the research behind the clinical trials of the drug, which slowed clinical decline by 27% after 18 months of treatment compared with those who received a placebo.  Sold under the brand name Leqembi™ and made by Eisai in partnership with Biogen Inc., the drug is delivered by an intravenous infusion every two weeks. Lecanemab works by removing a sticky protein from the brain that is believed to cause Alzheimer’s disease to advance.  This is the first time in two decades that the FDA has granted full approval to a drug for Alzheimer’s, but there is also a “black box” warning on the medication—the agency’s strongest caution—because of safety concerns. While 96% of the effects related to the drug's infusion were such transitory symptoms as chills, aches, fever and rash, the FDA's "black box" warning alerted consumers about the risk of brain swelling and bleeding and that people with a gene mutation that increases their risk of Alzheimer’s disease are at greater risk of brain swelling on the treatment. The label also cautions against taking blood thinners while on the medication.

In addition to advances in drug treatment for AD, Dr. Gupta's documentary featured new research published by Dr. Dean Ornish,  the founder and president of the nonprofit Preventive Medicine Research Institute in Sausalito, CA and clinical professor of medicine at the University of California, San Francisco. Dr. Ornish's work has focused exclusively on lifestyle changes that can either prevent, slow down or, in some cases, reverse the symptoms of AD. Some of the strongest evidence modifying risk factors for AD and other dementias comes from research that links brain health to heart health. The risk of developing AD or vascular dementia appears to increase with many conditions that damage the heart and blood vessels. These include:


  • Diabetes
  • Mid-life high blood pressure
  • High cholesterol
  • Midlife obesity
  • Smoking
  • Physical inactivity
  • Poor diet
  • Stress
  • Lack of quality social interaction


Dr. Ornish and his colleagues found that lifestyle changes that address the risk factors for heart disease can prevent, and even reverse, it. The same lifestyle changes that reverse heart disease can also prevent AD and vascular dementia. Based upon his research, he recommends the following 9 steps which he claims will "ward off" dementia:


  1. Stay physically active. Walking, bicycling, gardening, tai chi, yoga and other exercise of about 30 minutes a day will provide a good blood flow to the brain and encourage new brain cell growth.
  2. Stick with a brain-healthy/heart-healthy diet. Limit the amount sugar and saturated fats you eat. Make sure to eat plenty of fruits, vegetables and whole grains.
  3. Stop smoking.
  4. Maintain a healthy weight.
  5. Stay socially active. Take a class at the local library or community college, volunteer, or just hang out with friends.
  6. Stay mentally active. Exercise your brain on a daily basis. Engage in mentally challenging work or other activities, like learning a foreign language, puzzles or games with friends.
  7. Get more quality sleep. Try for at least seven to eight hours a night. If you need help, free guided meditation apps are available on your smart phone, like “Insight Timer.”
  8. Limit alcohol consumption. If you drink alcohol, stick with no more than two drinks per day.
  9. Protect your head. Buckle your seat belt, wear your helmet when participating in sports, and “fall-proof” your home. Make sure floors are uncluttered, remove or tack down all scatter rugs, avoid using slippery wax on floors, and slip-proof the tub. Make sure the bath mat has a nonslip bottom and remove electrical or telephone cords from traffic areas.


Dr. Ornish' research suggests that combining good nutrition with mental, social and physical activities may have a greater benefit in maintaining or improving brain health than any single activity. A two-year clinical trial of older adults at risk for cognitive impairment showed that a combination of physical activity, nutritional guidance, cognitive training, social activities and management of heart health risk factors slowed cognitive decline.


As the Warnings Doctor, I applaud Dr. Sanjay Gupta for bringing attention to a disease that now afflicts 5 million Americans with one new case diagnosed every 66 seconds in our country, a disease, however, which now may have a promising future as far as potential treatments and lifestyle changes that may slow or even, perhaps, reverse its course.

TEXAS LEADS THE NATION: WARNING LABELS ON ADDITIVES

By Dr. Gerald Goldhaber • July 9, 2025
On June 22, 2025, Governor Greg Abbott signed Senate Bill 25 (SB25), known as the Make Texas Healthy Again Act. Beginning January 1, 2027, Texas will require prominent on-pack warning labels whenever food sold in the state contains any of 44 specific additives—including synthetic colorants like Red 40, Yellow 5, Blue 1, titanium dioxide, bleached flour, and partially hydrogenated oils. The mandated label must declare the following:

WARNING: FDA DELAYS IMPLEMENTATION OF RULE THAT WOULD REQUIRE NEW NUTRITION LABELING

By Dr. Gerald Goldhaber • May 27, 2025
The FDA is delaying implementation of a rule that would require food companies to print nutritional information on the front labels of their products. The proposed rule was developed by President Biden’s Administration, with a comment period scheduled to close on May 16. The rule is designed to help consumers make better choices to avoid chronic health problems. Such problems—and consumer choices about nutrition—are things President Trump’s Secretary of Health and Human Services, Robert F. Kennedy Jr., has repeatedly touted. Even though hundreds of comments have been filed about the proposed rule, Kennedy’s Food and Drug Administration is delaying the close of the comment period by 60 days. Most of the comments filed so far have come from food companies and food industry trade organizations. “ A 60-day comment period extension allows adequate time for interested parties to submit comments while also not significantly delaying rulemaking on the important issues in the proposed rule ,” according to the FDA’s announcement about the delay. 

WARNING: THE GENDER BIAS IN CAR SAFETY TESTING PRESENTS AN ONGOING DANGER

By Dr. Gerald Goldhaber • April 30, 2025
Car accidents are a leading cause of injury and death worldwide, yet the safety measures designed to protect occupants in these life-or-death situations have long ignored a critical reality: women are more likely to be severely injured or killed in crashes than men. This disparity isn't rooted in biology alone—it’s also a result of a troubling oversight in the automotive industry’s safety testing protocols. For decades, crash-test dummies, which serve as proxies for human passengers in simulated collisions, have been modeled after the average male physique, leaving women out of the equation entirely. The Alarming Data Gap The implications of this gender gap in safety testing are both staggering and infuriating. Women, on average, have different body compositions than men—they tend to be shorter, lighter, and have different muscle distributions and bone densities. These physiological differences mean that women’s bodies interact with car safety features—such as seat belts, airbags, and headrests—in distinct ways. When vehicles aren’t tested with dummies that accurately represent female anatomy, crucial data about how to better protect women in crashes is simply ignored. Studies have revealed the dire consequences of this exclusion. Research from the University of Virginia found that women are 47% more likely to sustain serious injuries in car accidents compared to men, even when accounting for variables like seatbelt usage and crash severity. Women are also significantly more likely to suffer whiplash injuries due to the positioning of headrests, which are often designed with men’s neck dimensions in mind. These statistics aren’t just numbers—they represent lives cut short, families broken, and untold suffering that could have been mitigated with equitable safety testing.

WARNING: ARE MUSK, KENNEDY, AND TRUMP IGNORING THE GRAVE CONSEQUENCES OF SLASHING PUBLIC HEALTH FUNDING?

By Dr. Gerald Goldhaber • April 14, 2025
Recent budget cuts at the Health and Safety Science Services (HSSS) have sent shockwaves through the scientific and public health communities, threatening the very infrastructure designed to protect us from disease outbreaks, food contamination, and medical crises. These cuts have affected food inspectors, vaccine scientists, Alzheimer’s researchers, and experts studying bird flu, among others—positions that are essential to ensuring public safety and advancing critical medical research. The consequences of these decisions will be dire, potentially reversing years of progress and exposing society to increased health risks.

WARNING: IS ELON MUSK'S DEPARTMENT OF GOVERNMENT EFFICIENCY JEOPARDIZING AIR SAFETY?

By Dr. Gerald Goldhaber • March 12, 2025
As Elon Musk's Department of Government Efficiency (DGE) pushes for sweeping reforms and cost-cutting across federal agencies, concerns are mounting over the impact on critical public safety roles. Among the most alarming areas affected is the Federal Aviation Administration (FAA), where staff reductions may threaten the lives of millions of air travelers. The DGE, established with a mandate to streamline government operations and reduce bureaucratic waste, has come under fire for its aggressive downsizing tactics. Critics warn that essential safety personnel, including air traffic controllers, are being cut under the guise of efficiency, leaving the nation's airspace dangerously understaffed.

WARNING: WILL TRUMP'S SURGEON GENERAL SUPPORT IMPROVED ALCOHOL WARNING LABELS?

By Dr. Gerald Goldhaber • February 11, 2025
Biden Administration former Surgeon General, Vivek Murthy, on his way out of office, issued a Surgeon General's Advisory calling for new warnings on alcoholic beverages related to the cancer risk from consuming alcoholic beverages. Given that most individuals are unaware of the connection that consumption of alcoholic beverages can increase the risk for at least seven types of cancer, Murthy said in his advisory: "Given the conclusive evidence on the cancer risk from alcohol consumption and the Office of the Surgeon General's responsibility to inform the American public of the best available scientific evidence, the Surgeon General recommends an update to the Surgeon General's warning label for alcohol-containing beverages to include a cancer risk warning."

WARNING: TRUMP'S RE-ELECTION MEANS A DEREGULATORY NIGHTMARE FOR CONSUMERS

By Dr. Gerald Goldhaber • December 2, 2024
In my best-selling book, Murder, Inc.: How Unregulated Industry Kills or Injures Thousands of Americans Every Year...And What You Can Do About It , I propose a safety triad consisting of three components: manufacturers, regulators and consumers. All three must function properly in order to keep us safe. Manufacturers must produce and market safe (or safe as possible) products and warn us about any potential hazards so that we can make informed choices about whether or not to purchase their product and/or how to use it safely. Regulators , by imposing and implementing necessary rules and regulations, should hold manufacturers accountable for the above stated actions and to endure that they engage in "principled disclosure" by warning us about any potential hazards and dangers associated with their products. And, finally, Consumers , especially in the absence of well-meaning manufacturers or competent, well-intentioned regulators, must be highly diligent by researching products and learning about potential hazards prior to buying and/or using them. All three, manufacturers, regulators and consumers, must perform their jobs or the safety triad may fail to protect us and our loved ones. Think of a three-legged stool that distributes the weight of a person sitting on the stool, equally among the three legs. But what would happen if we leaned heavily to one side of the stool, essentially spreading the weight that was once borne by three legs to the two legs remaining braced to the floor. Unfortunately the third leg is no longer contributing to the stability of the stool, which may actually collapse because the two remaining legs may not be able to handle the amount of weight that was intended to be equally distributed among all three legs. 

WARNING: FDA RECOMMENDS REMOVING POPULAR DECONGESTANT FROM MARKET

By Dr. Gerald Goldhaber • November 15, 2024
If you or anyone in your family has used, uses or plans to use such over the counter (OTC) remedies for the flu or common cold as Theraflu, Robitussin, NyQuil, DayQuil, Mucinex, Sudafed or even some versions of Tylenol or Advil, you may want to read this newsletter very carefully.

WARNING: SOCIAL MEDIA IS ASSOCIATED WITH SIGNIFICANT MENTAL HEALTH HARMS FOR ADOLESCENTS

By Gerald Goldhaber • October 2, 2024
In an unprecedented, but, according to many social scientists and parents, a long overdue action, Surgeon General Vivek Murthy, in a June editorial in the New York Times, called for a warning label to be placed on all social media platforms. In the words of the Surgeon General:

WARNING: DOES YOUR REFRIGERATOR CONTAIN LISTERIA?

By Gerald Goldhaber • September 5, 2024
If you are one of the millions of Americans who recently purchased one of several Boar's Head Deli Products, you may have bought a product containing deadly listeria bacteria. At least nine people have died and 57 have been hospitalized from a listeria outbreak linked to deli meat, according to the Centers for Disease Control and Prevention. In late July, Boar’s Head, a deli meat and cheese company, expanded a previously announced recall to include at least 7 million pounds of deli products the company says may have been contaminated by listeria amid a nationwide outbreak. The recall spans 71 products and includes meat meant to be sliced at retail delis along with prepackaged meat and poultry products sold at retail locations, according to the U.S. Department of Agriculture.
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